Saizen Liquid 12mg (8mg/ml) Pre-filled Pen 1.50ml x1 (pen)

Saizen Liquid 12mg (8mg/ml) Pre-filled Pen is a prescription-only recombinant human growth hormone belonging to the somatropin drug class, with somatropin as its active ingredient — a biosynthetic form of the naturally occurring growth hormone produced in the human body. This ready-to-use pre-filled pen device is designed for subcutaneous (under-the-skin) injection, making administration more convenient and precise compared to traditional vial-and-syringe preparations.

Like all medicines, Saizen may cause some side effects in certain individuals, including injection site reactions, headaches, fluid retention, and joint or muscle discomfort — though not everyone will experience these. Before you start using this medicine, it is important that you understand the correct dosage, storage requirements, and any precautions that apply to you personally, so please always follow your doctor's instructions carefully and never self-prescribe.

The dosage of Saizen is highly individualised and determined by your doctor based on your body weight, medical condition, and response to treatment — generally ranging from 0.025 mg/kg to 0.035 mg/kg per day for growth hormone deficiency in adults and children, administered once daily. Never adjust your dose on your own; always follow the specific dosage schedule prescribed by your healthcare provider to ensure safe and effective therapy.

• Injection site reactions such as pain, redness, swelling, or bruising
• Headache
• Fluid retention (oedema) — noticeable as swelling in the hands, feet, or ankles
• Joint pain (arthralgia) or muscle pain (myalgia)
• Fatigue or general weakness

• Carpal tunnel syndrome (numbness or tingling in the hands and wrists)
• Increased blood glucose levels or reduced insulin sensitivity
• Skin reactions such as rash or itching
• Pins and needles sensation (paraesthesia)
• Localised lipoatrophy (loss of fatty tissue at the injection site)

• Intracranial hypertension (increased pressure in the brain) — symptoms may include severe headache, vision changes, or nausea
• Slipped capital femoral epiphysis (hip or knee pain in paediatric patients)
• Pancreatitis (severe abdominal pain)
• Hypothyroidism (reduced thyroid function)
• Gynaecomastia (breast tissue enlargement in males)

Store unopened Saizen pre-filled pens in a refrigerator at 2°C to 8°C (36°F to 46°F).

• Do not freeze the product—freezing will damage the solution and render it unsafe for use.
• Keep the pen away from direct light and store it in its original carton to protect it from light exposure.
• Once in use, the pen may be stored at room temperature below 25°C for up to 28 days, or continued to be kept in the refrigerator.
• Keep this medicine out of the reach and sight of children at all times.
• Do not use the solution if it appears cloudy, discoloured, or contains visible particles—a properly prepared solution should be clear and colourless.
• Dispose of used pens and needles safely in a sharps disposal container as advised by your pharmacist or healthcare provider.

• Use Saizen only under the supervision of a licensed healthcare professional and follow the prescribed dosage instructions.
• Check the expiry date and inspect the solution before each use. The solution should be clear and colourless.
• Rotate injection sites regularly to help minimise skin irritation and tissue changes.
• Do not share your pre-filled pen with others, even if the needle has been changed.
• Store unopened pens in the refrigerator at 2°C–8°C and never freeze them.
• Discard the pen 28 days after first use, even if some solution remains.
• Dispose of used needles and pens safely in an approved sharps container.
• Attend regular follow-up appointments and purchase Saizen only from licensed pharmacies.

Saizen Liquid 12mg (8mg/ml) Pre-filled Pen is administered as a subcutaneous injection, typically into the skin of the abdomen, thigh, or upper arm — and your doctor or trained healthcare professional will show you exactly how to use the pen device correctly before you begin. It is important to rotate injection sites with each dose to prevent skin irritation or lipodystrophy (changes in the fatty tissue under the skin) at the injection area. Always follow your prescribing doctor's specific instructions regarding timing, technique, and frequency, as individual administration guidance may vary depending on your treatment plan.

Saizen Liquid 12mg (8mg/ml) Pre-filled Pen has a shelf life of 24 months from the date of manufacture when stored under the recommended conditions. Once the pen cartridge has been opened or is in use, it should be used within 28 days and must not be used beyond this period, even if solution remains in the pen. Always check the expiry date printed on the packaging before use and do not use the product if it has expired.

The active ingredient in Saizen Liquid 12mg (8mg/ml) Pre-filled Pen is Somatropin (rDNA origin) — a recombinant human growth hormone that is biosynthetically produced using DNA recombinant technology and is structurally identical to the growth hormone naturally secreted by the human pituitary gland. Each millilitre of the solution contains 8mg of somatropin, with each pre-filled pen delivering a total of 12mg of the active substance.

Saizen Liquid 12mg (8mg/ml) Pre-filled Pen should not be used in the following situations:

• Active malignancy (cancer): Saizen must not be used in patients with active or suspected cancer. Anti-tumour therapy must be completed before initiating growth hormone treatment.
• Acute critical illness: Patients suffering from complications following open heart surgery, abdominal surgery, multiple accidental trauma, or acute respiratory failure should not use Saizen.
• Closed epiphyses in children: Saizen should not be used for growth promotion in children whose bone growth plates have already closed.
• Diabetic retinopathy: Saizen is contraindicated in patients with active proliferative or severe non-proliferative diabetic retinopathy.
• Known hypersensitivity: Patients with a known allergy or hypersensitivity to somatropin or any of the excipients in the formulation must not use this product.
• Prader-Willi Syndrome with severe obesity or respiratory impairment: Saizen should not be used in paediatric patients with Prader-Willi Syndrome who have severe obesity, a history of upper airway obstruction, sleep apnoea, or severe respiratory illness.

Always inform your doctor of your full medical history before commencing Saizen therapy.

• Corticosteroids (e.g., prednisolone, hydrocortisone): Long-term or high-dose corticosteroid therapy may reduce the growth-promoting effects of somatropin. Dose adjustments may be required.
• Insulin and oral antidiabetic agents: Somatropin may reduce insulin sensitivity, potentially requiring adjustment of antidiabetic medication dosages in diabetic patients.
• CYP450-metabolised drugs: Somatropin may alter the metabolism of drugs processed by liver enzymes, including cyclosporine, sex steroids, anticonvulsants, and certain cardiovascular medicines. Dose monitoring may be necessary.
• Thyroid hormone replacement therapy: Saizen may unmask or worsen hypothyroidism, and patients on thyroid replacement therapy may require dose adjustments.
• Glucocorticoid replacement therapy: In patients with hypopituitarism, glucocorticoid replacement should be optimised before starting Saizen, as growth hormone can affect cortisol metabolism.
• Oestrogens (oral): Women taking oral oestrogen therapy may require higher doses of somatropin due to reduced IGF-1 response.

• There are no known clinically significant food interactions with Saizen. However, maintaining a balanced, nutritious diet as advised by your healthcare provider supports the overall effectiveness of your treatment plan.

1. Can I buy Saizen Liquid 12mg (8mg/ml) Pre-filled Pen online in Malaysia?
Yes, you can purchase Saizen Liquid 12mg (8mg/ml) Pre-filled Pen through our licensed online pharmacy in Malaysia. We are a registered pharmaceutical retailer operating in compliance with Malaysian pharmacy regulations, and we only dispense prescription medicines upon verification of a valid prescription from a licensed doctor.

2. Do I need a prescription to order Saizen Liquid 12mg Pre-filled Pen in Malaysia?
Yes, absolutely. Saizen is a prescription-only medicine (POM) in Malaysia. You will be required to submit a valid prescription issued by a registered medical practitioner before your order can be processed and dispensed. This is a legal and safety requirement that we strictly follow to protect your health.

3. How do I submit my prescription when ordering online?
It's simple and convenient! You can upload a clear photo or scanned copy of your valid doctor's prescription during the checkout process on our website. Our licensed pharmacist will review and verify your prescription before your order is approved and dispatched. If you have any questions about the process, our customer support team is happy to guide you.

4. How do I know the Saizen I receive is genuine and not counterfeit?
We source all our pharmaceutical products directly from authorised distributors and licensed importers in Malaysia. Saizen purchased from our pharmacy will come in its original manufacturer packaging, complete with batch numbers, expiry dates, and authenticity markers. We strongly advise against purchasing prescription medicines from unverified or unlicensed sources to protect your safety.

5. Does your online pharmacy deliver Saizen across Malaysia?
Yes! We offer delivery to all states across Peninsular Malaysia, Sabah, and Sarawak. Cold-chain delivery packaging is used for temperature-sensitive medicines like Saizen to ensure the product remains within the required refrigeration temperature (2°C to 8°C) throughout transit. Delivery timeframes and charges may vary depending on your location.

6. How is Saizen packaged during delivery to ensure it stays cold?
We take product integrity very seriously. Saizen pre-filled pens are packed in insulated cold-chain packaging with appropriate cooling materials (such as gel ice packs) to maintain the required storage temperature during transit. Please refrigerate the product immediately upon receiving your delivery.

7. What should I do if my Saizen pen arrives damaged or appears to have been compromised during delivery?
If your order arrives damaged, leaking, or you have any concerns about the condition of the product upon delivery, please do not use it. Contact our customer service team immediately with photos of the packaging and product, and we will assist you with a replacement or resolution as quickly as possible.

8. Is Saizen Liquid 12mg Pre-filled Pen available in stock in Malaysia?
Stock availability may vary. We recommend checking the product listing on our website for real-time stock status or contacting our pharmacy team directly. You can also register for stock availability notifications so you are alerted as soon as the product is available for order.

9. Can I get a refund or return Saizen if I change my mind after purchasing?
Due to the nature of prescription medicines and the strict cold-chain storage requirements for Saizen, returns and refunds are generally not accepted once the product has been dispensed and delivered, in accordance with Malaysian pharmaceutical regulations. However, if there is a genuine issue with your order (such as a wrong item or damaged product), please contact us and we will do our best to resolve it fairly.

10. How can I be sure your online pharmacy is legitimate and safe to purchase from in Malaysia?
Our pharmacy operates under the regulatory framework of the Ministry of Health Malaysia (MOH) and adheres to all applicable pharmaceutical dispensing laws. We only stock registered medicines approved by the National Pharmaceutical Regulatory Agency (NPRA). You are welcome to contact us directly if you would like to verify our credentials or have any concerns about ordering from us—your safety and trust are our top priorities.